Description

2-(2,4-Dichloro-Phenyl)-6-Hydroxy-1,2,3,4-Tetrahydro-Isoquinoline-1-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure. This compound is of significant value in medicinal chemistry for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, particularly within the fields of central nervous system (CNS) and anti-infective drug discovery.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of complex drug candidates and novel chemical entities (NCEs).
• Medicinal Chemistry Research: Used as a scaffold or building block in structure-activity relationship (SAR) studies and lead optimization programs.
• Active Pharmaceutical Ingredient (API) Development: A key raw material in the pilot-scale and commercial-scale production of target APIs, especially those with isoquinoline-based pharmacophores.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for the pharmaceutical industry.
• Biochemical Research: May be utilized in biochemical assays and as a tool compound for investigating specific biological pathways or enzyme interactions.

Basic Information

Product Name	2-(2,4-Dichloro-Phenyl)-6-Hydroxy-1,2,3,4-Tetrahydro-Isoquinoline-1-Carboxylic Acid
CAS No.	1260643-03-5
Molecular Formula	C₁₆H₁₃Cl₂NO₃
Molecular Weight	338.19 g/mol
Synonyms	6-Hydroxy-2-(2,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid; 2-(2,4-Dichlorophenyl)-6-hydroxy-1,2,3,4-tetrahydro-1-isoquinolinecarboxylic acid; 1,2,3,4-Tetrahydro-6-hydroxy-2-(2,4-dichlorophenyl)-1-isoquinolinecarboxylic acid; CAS 1260643-03-5; 2-(2,4-Dichlorophenyl)-6-hydroxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid; 6-Hydroxy-2-(2,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-isoquinolinecarboxylic acid.
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Quality Control

Our 2-(2,4-Dichloro-Phenyl)-6-Hydroxy-1,2,3,4-Tetrahydro-Isoquinoline-1-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets the highest standards of purity and consistency required for pharmaceutical R&D and manufacturing. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and away from direct light sources to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.