Description

7-Fluoro-1,2,3,4-Tetrahydro-Isoquinoline-1-Carboxylic Acid is a high-value fluorinated heterocyclic building block essential for modern pharmaceutical research and development. This compound serves as a critical intermediate in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the development of new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key synthon for the construction of complex drug candidates, especially in medicinal chemistry programs.
• API Synthesis: Used in the research and development of novel Active Pharmaceutical Ingredients, leveraging the fluorine atom for enhanced metabolic stability and bioavailability.
• Neurological Drug Discovery: Serves as a core scaffold for developing potential therapeutics for CNS conditions such as depression, anxiety, and neurodegenerative diseases.
• Chemical Biology Probes: Employed in the design and synthesis of fluorinated probes for studying biological targets and pathways.
• Process Chemistry & Scale-Up: Suitable for use in route scouting and optimization for the commercial-scale production of fluorinated pharmaceuticals.
• Academic & Industrial Research: A valuable reagent for synthetic organic chemists in both university and industrial settings exploring new chemical entities.

Basic Information

Product Name	7-Fluoro-1,2,3,4-Tetrahydro-Isoquinoline-1-Carboxylic Acid
CAS No.	1260641-74-4
Molecular Formula	C10H10FNO2
Molecular Weight	195.19 g/mol
Synonyms	7-Fluoro-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid; 1,2,3,4-Tetrahydro-7-fluoro-1-isoquinolinecarboxylic acid; 7-Fluoro-THIQ-1-COOH; 7-Fluoro-1,2,3,4-tetrahydro-1-isoquinolinecarboxylic acid; 7-Fluoro-1,2,3,4-tetrahydroisoquinoline-1-carboxylate; 7-Fluoro-1-carboxy-1,2,3,4-tetrahydroisoquinoline; 7-Fluoro-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid (CAS 1260641-74-4)
EINECS	Contact for details

Quality Control

Our 7-Fluoro-1,2,3,4-Tetrahydro-Isoquinoline-1-Carboxylic Acid is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for research and development applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as assay, purity by HPLC, and identification. Our quality system is designed to meet the stringent requirements of pharmaceutical and fine chemical industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed to prevent exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.