Description

Ethyl 2-(4-Fluoro-Phenyl)-6-Fluoro-1,2,3,4-Tetrahydro-Isoquinoline-1-Carboxylate is a high-purity, fluorinated tetrahydroisoquinoline derivative, a critical building block in modern pharmaceutical synthesis. Its value lies in its precise molecular architecture, which serves as a key intermediate for developing novel active pharmaceutical ingredients (APIs) with targeted therapeutic effects. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly those focused on central nervous system (CNS) agents, anti-infectives, and other specialized drug discovery programs.

Application

• Pharmaceutical Intermediate: A crucial synthetic precursor for the development of novel drug candidates, especially in neurological and psychiatric disorder research.
• Active Pharmaceutical Ingredient (API) Synthesis: Used in the multi-step synthesis of complex fluorinated pharmaceutical compounds.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery.
• Agrochemical Intermediate: Potential application in the synthesis of advanced, fluorinated crop protection agents and pesticides.
• Chemical Biology Probes: Used to create labeled compounds or probes for studying biological pathways and target engagement.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for the life sciences sector.

Basic Information

Item	Details
Product Name	Ethyl 2-(4-Fluoro-Phenyl)-6-Fluoro-1,2,3,4-Tetrahydro-Isoquinoline-1-Carboxylate
CAS No.	1260641-34-6
Molecular Formula	C18H17F2NO2
Molecular Weight	317.33 g/mol
Synonyms	Ethyl 2-(4-fluorophenyl)-6-fluoro-1,2,3,4-tetrahydroisoquinoline-1-carboxylate; 1,2,3,4-Tetrahydroisoquinoline-1-carboxylic acid, 2-(4-fluorophenyl)-6-fluoro-, ethyl ester; 2-(4-Fluorophenyl)-6-fluoro-1,2,3,4-tetrahydro-1-isoquinolinecarboxylic acid ethyl ester; 1260641-34-6; Ethyl 2-(p-fluorophenyl)-6-fluoro-1,2,3,4-tetrahydroisoquinoline-1-carboxylate; Fluorinated THIQ derivative; F-Phenyl-F-THIQ ethyl ester
EINECS	Contact for details

Quality Control

Our production of Ethyl 2-(4-Fluoro-Phenyl)-6-Fluoro-1,2,3,4-Tetrahydro-Isoquinoline-1-Carboxylate adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with your research or cGMP-grade requirements. Our quality system is designed to deliver consistent purity and reliable supply for critical pharmaceutical development work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.