Description

2-(4-Chloro-Phenyl)-6-Fluoro-1,2,3,4-Tetrahydro-Isoquinoline-1-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate with the CAS registry number 1260641-23-3. This compound is critical for the research and development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex heterocyclic scaffolds. It is primarily sought by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of innovative drug candidates.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates targeting central nervous system (CNS) disorders, oncology, and anti-inflammatory pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its unique tetrahydroisoquinoline core.
• API Development: Serves as a precursor in the multi-step synthesis of complex target molecules for preclinical and clinical development.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and scale-up of pharmaceutical compounds.
• Chemical Reference Standard: Utilized as a high-purity analytical standard for method development and quality control in pharmaceutical analysis.
• Academic Research: Employed in university and institutional labs for exploring new synthetic methodologies and bioorganic chemistry.

Basic Information

Product Name	2-(4-Chloro-Phenyl)-6-Fluoro-1,2,3,4-Tetrahydro-Isoquinoline-1-Carboxylic Acid
CAS No.	1260641-23-3
Molecular Formula	C16H13ClFNO2
Molecular Weight	305.73 g/mol
Synonyms	6-Fluoro-2-(4-chlorophenyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid; 2-(4-Chlorophenyl)-6-fluoro-1,2,3,4-tetrahydro-1-isoquinolinecarboxylic acid; 1,2,3,4-Tetrahydro-2-(4-chlorophenyl)-6-fluoro-1-isoquinolinecarboxylic acid; 1260641-23-3; 2-(p-Chlorophenyl)-6-fluoro-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid
EINECS	Contact for details

Quality Control

Our 2-(4-Chloro-Phenyl)-6-Fluoro-1,2,3,4-Tetrahydro-Isoquinoline-1-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and stringent control of residual solvents and impurities. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5%, Total impurities ≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.