Description

6-Bromo-2-(2,4-Dichloro-Phenyl)-1,2,3,4-Tetrahydro-Isoquinoline-1-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. This compound is valued for its complex heterocyclic structure, which serves as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily sought after by pharmaceutical R&D departments and fine chemical manufacturers engaged in developing new therapeutic agents, particularly within medicinal chemistry programs targeting central nervous system and anti-infective applications.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new drug candidates, especially for central nervous system (CNS) disorders.
• Medicinal Chemistry Research: Used as a core scaffold or building block for structure-activity relationship (SAR) studies and library synthesis in drug discovery.
• API Synthesis: Employed in the multi-step synthesis of complex target molecules for pre-clinical and clinical trial material production.
• Chemical Reference Standard: Serves as a high-purity standard for analytical method development, validation, and quality control in pharmaceutical manufacturing.
• Academic & Institutional Research: Utilized in universities and research institutes for studying heterocyclic chemistry, reaction mechanisms, and novel synthetic pathways.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP guidelines.

Basic Information

Product Name	6-Bromo-2-(2,4-Dichloro-Phenyl)-1,2,3,4-Tetrahydro-Isoquinoline-1-Carboxylic Acid
CAS No.	1260640-29-6
Molecular Formula	C₁₆H₁₂BrCl₂NO₂
Molecular Weight	401.08 g/mol
Synonyms	6-Bromo-2-(2,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid; 1,2,3,4-Tetrahydro-6-bromo-2-(2,4-dichlorophenyl)isoquinoline-1-carboxylic acid; 1260640-29-6; 6-Bromo-2-(2,4-dichlorophenyl)-3,4-dihydro-1H-isoquinoline-1-carboxylic acid; Tetrahydroisoquinoline-1-carboxylic acid, 6-bromo-2-(2,4-dichlorophenyl)-; 2-(2,4-Dichlorophenyl)-6-bromo-1,2,3,4-tetrahydroisoquinoline-1-carboxylic Acid
EINECS	Contact for details

Quality Control

Our 6-Bromo-2-(2,4-Dichloro-Phenyl)-1,2,3,4-Tetrahydro-Isoquinoline-1-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure it meets the exacting standards required for pharmaceutical R&D and cGMP applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.