Description

7-Bromo-1,2,3,4-Tetrahydro-Isoquinoline-1-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate with a distinct brominated tetrahydroisoquinoline scaffold. This compound is a critical building block in organic synthesis, valued for its role in constructing complex molecules with potential biological activity. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, particularly those targeting neurological and cardiovascular disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its versatile chemical handle.
• Organic Synthesis Building Block: Employed in the construction of complex heterocyclic compounds and natural product analogs.
• Chemical Reference Standard: Supplied as a high-purity standard for analytical method development and quality control in API manufacturing.
• Bioconjugation & Probe Development: The carboxylic acid functionality allows for conjugation to biomolecules or solid supports for biochemical research.

Basic Information

Product Name	7-Bromo-1,2,3,4-Tetrahydro-Isoquinoline-1-Carboxylic Acid
CAS No.	1260640-00-3
Molecular Formula	C10H10BrNO2
Molecular Weight	256.10 g/mol
Synonyms	7-Bromo-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid; 1,2,3,4-Tetrahydro-7-bromo-1-isoquinolinecarboxylic acid; 7-Bromo-THIQ-1-COOH; 7-Bromo-1-carboxy-1,2,3,4-tetrahydroisoquinoline; 1260640-00-3; 7-Bromo-1,2,3,4-tetrahydro-1-isoquinolinecarboxylic acid; 7-Bromotetrahydroisoquinoline-1-carboxylic acid
EINECS	Contact for details

Quality Control

Our 7-Bromo-1,2,3,4-Tetrahydro-Isoquinoline-1-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area%)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.