Description

Ethyl 2-(4-Fluoro-Phenyl)-6-Chloro-1,2,3,4-Tetrahydro-Isoquinoline-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate of significant importance in modern drug discovery and development. This compound serves as a critical building block for synthesizing novel therapeutic agents, particularly within the central nervous system (CNS) and oncology research fields. It is primarily required by pharmaceutical R&D laboratories, contract research and manufacturing organizations (CROs/CMOs), and fine chemical suppliers engaged in the production of complex, biologically active molecules.

Application

• Pharmaceutical Intermediate: Key synthetic precursor for the development of novel tetrahydroisoquinoline-based drug candidates.
• Neurological Research: Building block for potential therapeutics targeting CNS disorders, such as depression, anxiety, or neurodegenerative diseases.
• Oncology Drug Discovery: Used in the synthesis of experimental compounds for cancer treatment research.
• Chemical Biology: Serves as a probe or scaffold in medicinal chemistry for structure-activity relationship (SAR) studies.
• Process Chemistry: Employed in route scouting and scale-up optimization for the manufacture of active pharmaceutical ingredients (APIs).
• Custom Synthesis: Starting material for the bespoke production of specialized fine chemicals and research compounds.

Basic Information

Product Name	Ethyl 2-(4-Fluoro-Phenyl)-6-Chloro-1,2,3,4-Tetrahydro-Isoquinoline-1-Carboxylate
CAS No.	1260639-13-1
Molecular Formula	C18H17ClFNO2
Molecular Weight	333.79 g/mol
Synonyms	Ethyl 2-(4-fluorophenyl)-6-chloro-1,2,3,4-tetrahydroisoquinoline-1-carboxylate; 1-Carbethoxy-2-(4-fluorophenyl)-6-chloro-1,2,3,4-tetrahydroisoquinoline; 6-Chloro-2-(4-fluorophenyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid ethyl ester; 1260639-13-1; UNII-9J6K9W8P6F; SCHEMBL21806227; AKOS040759623; ZINC000253899977
EINECS	Contact for details

Quality Control

Our Ethyl 2-(4-Fluoro-Phenyl)-6-Chloro-1,2,3,4-Tetrahydro-Isoquinoline-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specification results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and consistency for critical R&D and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be light-sensitive and should be handled under appropriate conditions to maintain stability. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.