Description

Ethyl 2-(4-Fluoro-Phenyl)-6-Bromo-1,2,3,4-Tetrahydro-Isoquinoline-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate with the CAS registry number 1260639-01-7. This compound is a critical building block in modern medicinal chemistry, valued for its complex heterocyclic structure that serves as a core scaffold for drug discovery. It is primarily sought by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly within the fields of central nervous system (CNS) and oncology research.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the multi-step synthesis of active pharmaceutical ingredients (APIs) targeting specific biological pathways.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• CNS Drug Development: Its tetrahydroisoquinoline core is a privileged structure in the design of compounds for neurological and psychiatric disorders.
• Oncological Research: Employed in the synthesis of potential kinase inhibitors and other targeted cancer therapies.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for client projects.
• Academic Research: Utilized in university and institutional labs for exploratory synthetic chemistry and pharmacological studies.

Basic Information

Product Name	Ethyl 2-(4-Fluoro-Phenyl)-6-Bromo-1,2,3,4-Tetrahydro-Isoquinoline-1-Carboxylate
CAS No.	1260639-01-7
Molecular Formula	C18H17BrFNO2
Molecular Weight	378.24 g/mol
Synonyms	Ethyl 6-bromo-2-(4-fluorophenyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxylate; 1,2,3,4-Tetrahydroisoquinoline-1-carboxylic acid, 6-bromo-2-(4-fluorophenyl)-, ethyl ester; 6-Bromo-2-(4-fluorophenyl)-1,2,3,4-tetrahydro-1-isoquinolinecarboxylic acid ethyl ester; 1260639-01-7; CAS 1260639-01-7.
EINECS	Contact for details

Quality Control

Our Ethyl 2-(4-Fluoro-Phenyl)-6-Bromo-1,2,3,4-Tetrahydro-Isoquinoline-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and analytical methods is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep the container sealed to protect this light-sensitive material from degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Individual impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.