Description

6-Chloro-1,2,3,4-Tetrahydro-Isoquinoline-1-Carboxylic Acid Hydrochloride is a high-purity, synthetically derived organic compound that serves as a critical building block in advanced pharmaceutical research and development. Its value lies in its role as a versatile intermediate for constructing complex molecules, particularly in the synthesis of active pharmaceutical ingredients (APIs) and novel drug candidates. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries who require reliable, high-quality intermediates for their synthetic workflows.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug molecules and active pharmaceutical ingredients (APIs), particularly those targeting neurological and cardiovascular systems.
• Medicinal Chemistry Research: Used in the discovery and optimization of new therapeutic agents, enabling structure-activity relationship (SAR) studies.
• Process Chemistry Development: Serves as a starting material or intermediate in the scale-up and optimization of synthetic routes for commercial drug manufacturing.
• Fine Chemical Synthesis: Employed in the preparation of specialty chemicals, advanced materials, and other complex organic compounds requiring the tetrahydroisoquinoline scaffold.
• Contract Research & Manufacturing (CRAM): Supplied to organizations providing custom synthesis and development services for the global pharmaceutical industry.

Basic Information

Product Name	6-Chloro-1,2,3,4-Tetrahydro-Isoquinoline-1-Carboxylic Acid Hydrochloride
CAS No.	1260638-90-1
Molecular Formula	C11H11Cl2NO2
Molecular Weight	260.12 g/mol
Synonyms	6-Chloro-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid hydrochloride; 1,2,3,4-Tetrahydro-6-chloro-1-isoquinolinecarboxylic acid hydrochloride; 6-Chloro-THIQ-1-COOH HCl; (1S)-6-Chloro-1,2,3,4-tetrahydro-1-isoquinolinecarboxylic acid hydrochloride (if applicable); 6-Cl-THIQ-1-CA HCl; 6-Chloro-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid HCl salt
EINECS	Contact for details

Quality Control

Every batch of 6-Chloro-1,2,3,4-Tetrahydro-Isoquinoline-1-Carboxylic Acid Hydrochloride undergoes rigorous analytical testing to ensure it meets the stringent purity and consistency standards required for pharmaceutical R&D. Our quality system is designed to provide full traceability and compliance with cGMP principles where applicable. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect stability and handling properties. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.