Description

2-Cbz-6-Fluoro-3,4-Dihydro-1H-Isoquinoline-1-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate featuring a protected isoquinoline scaffold. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel drug candidates targeting central nervous system and oncological pathways. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the production of complex bioactive molecules.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of potential therapeutic agents, especially those with isoquinoline-based structures.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new drug candidates.
• Protease Inhibitor Development: Serves as a precursor in the design and synthesis of inhibitors for various protease enzymes.
• Chemical Biology Probes: Employed in the creation of molecular probes for studying biological pathways and target validation.
• Custom Synthesis: A starting material for contract manufacturing organizations (CMOs) producing bespoke compounds for client-specific research programs.
• Academic Research: Utilized in university and institutional labs for exploratory synthetic chemistry and pharmacology projects.

Basic Information

Item	Details
Product Name	2-Cbz-6-Fluoro-3,4-Dihydro-1H-Isoquinoline-1-Carboxylic Acid
CAS No.	1260638-89-8
Molecular Formula	C18H16FNO4
Molecular Weight	329.32 g/mol
Synonyms	1-Carbobenzyloxy-6-fluoro-3,4-dihydroisoquinoline-1-carboxylic acid; 6-Fluoro-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid N-benzyloxycarbonyl derivative; 2-[(Benzyloxy)carbonyl]-6-fluoro-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid; 2-Cbz-6-Fluoro-Tic-OH; 6-Fluoro-2-N-Cbz-1,2,3,4-tetrahydroisoquinoline-1-carboxylic Acid; N-Carbobenzyloxy-6-fluoro-1,2,3,4-tetrahydroisoquinoline-1-carboxylic Acid; 2-(Benzyloxycarbonyl)-6-fluoro-3,4-dihydro-1H-isoquinoline-1-carboxylic acid
EINECS	Contact for details

Quality Control

Our 2-Cbz-6-Fluoro-3,4-Dihydro-1H-Isoquinoline-1-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the exacting standards required for pharmaceutical research. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.