Description

2-Cbz-6-Chloro-3,4-Dihydro-1H-Isoquinoline-1-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate featuring a protected carboxylic acid and a chloro-substituted isoquinoline core. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of complex bioactive molecules. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing new therapeutic agents, particularly in the areas of central nervous system (CNS) and oncology drug discovery.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the multi-step synthesis of novel drug candidates and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Protease Inhibitor Synthesis: Serves as a core building block for the development of protease inhibitors, leveraging the isoquinoline structure.
• CNS Drug Development: Employed in the research of potential therapeutics for neurological disorders due to the pharmacophore relevance of the dihydroisoquinoline moiety.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP guidelines.
• Academic Research: Used in university and institutional laboratories for organic synthesis methodology development and pharmacological studies.

Basic Information

Product Name	2-Cbz-6-Chloro-3,4-Dihydro-1H-Isoquinoline-1-Carboxylic Acid
CAS No.	1260638-63-8
Molecular Formula	C18H16ClNO4
Molecular Weight	345.78 g/mol
Synonyms	1-[(Benzyloxy)carbonyl]-6-chloro-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid; 6-Chloro-2-[(phenylmethoxy)carbonyl]-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid; 2-(Benzyloxycarbonyl)-6-chloro-1,2,3,4-tetrahydroisoquinoline-1-carboxylic Acid; 2-Cbz-6-Cl-Tic-OH; 6-Chloro-2-Cbz-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid; 2-Carbobenzyloxy-6-chloro-1,2,3,4-tetrahydroisoquinoline-1-carboxylic Acid
EINECS	Contact for details

Quality Control

Our 2-Cbz-6-Chloro-3,4-Dihydro-1H-Isoquinoline-1-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure compliance with research and development grade standards. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if opened for prolonged periods.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (IR)	Spectrum matches reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.