Description

2-Cbz-6-Bromo-3,4-Dihydro-1H-Isoquinoline-1-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate designed for complex organic synthesis. This compound matters because it serves as a critical building block for the development of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry research. Pharmaceutical R&D laboratories and fine chemical manufacturers need this material for constructing complex heterocyclic scaffolds, enabling the synthesis of potential drug candidates targeting a range of therapeutic areas.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of novel drug candidates, especially those containing the isoquinoline pharmacophore.
• Medicinal Chemistry Research: Used in hit-to-lead optimization and structure-activity relationship (SAR) studies to develop new therapeutic agents.
• API Development: Serves as a building block in the synthesis of complex Active Pharmaceutical Ingredients (APIs) for preclinical and clinical development.
• Chemical Biology Probes: Utilized in the creation of specialized molecular probes for studying biological pathways and target validation.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for bespoke synthesis projects on behalf of pharmaceutical clients.
• Academic Research: Used in university and institutional laboratories for fundamental research in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	2-Cbz-6-Bromo-3,4-Dihydro-1H-Isoquinoline-1-Carboxylic Acid
CAS No.	1260638-55-8
Molecular Formula	C18H16BrNO4
Molecular Weight	390.23 g/mol
Synonyms	2-[(Benzyloxy)carbonyl]-6-bromo-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid; 6-Bromo-2-(carbobenzyloxy)-1,2,3,4-tetrahydro-1-isoquinolinecarboxylic acid; 2-Cbz-6-Br-Tic-OH; 2-(Benzyloxycarbonyl)-6-bromo-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid; 6-Bromo-2-[(phenylmethoxy)carbonyl]-1,2,3,4-tetrahydro-1-isoquinolinecarboxylic acid; 1-Carboxy-6-bromo-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid benzyl ester
EINECS	Contact for details

Quality Control

Our 2-Cbz-6-Bromo-3,4-Dihydro-1H-Isoquinoline-1-Carboxylic Acid is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot is analyzed using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.