Description

6-Bromo-3,4-Dihydro-1H-Isoquinoline-1,2-Dicarboxylic Acid 2-tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its brominated isoquinoline core structure. This compound is of significant value for its role as a versatile building block in the synthesis of complex bioactive molecules, particularly in medicinal chemistry. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, including potential candidates for central nervous system (CNS) and oncology targets.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of novel drug candidates, particularly those targeting neurological and oncological pathways.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Organic Synthesis Building Block: Employed in multi-step synthetic routes to construct complex heterocyclic systems due to its reactive bromine and ester functionalities.
• Chemical Reference Standard: Serves as a high-purity analytical standard for quality control and method development in analytical laboratories.
• Academic Research: Utilized in university and institutional labs for studying organic reaction mechanisms and developing new synthetic methodologies.

Basic Information

Product Name	6-Bromo-3,4-Dihydro-1H-Isoquinoline-1,2-Dicarboxylic Acid 2-tert-Butyl Ester
CAS No.	1260638-11-6
Molecular Formula	C₁₆H₁₈BrNO₄
Molecular Weight	368.22 g/mol
Synonyms	6-Bromo-1,2,3,4-tetrahydroisoquinoline-1,2-dicarboxylic acid 2-tert-butyl ester; 2-(tert-Butyl) 1-ethyl 6-bromo-3,4-dihydro-1H-isoquinoline-1,2-dicarboxylate (common misassignment); 6-Bromo-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid tert-butyl ester; 6-Bromo-THIQ-1,2-dicarboxylic acid 2-tert-butyl ester; 1260638-11-6; tert-Butyl 6-bromo-1,2,3,4-tetrahydroisoquinoline-2-carboxylate-1-carboxylate; 6-Bromoisoquinoline-1,2-dicarboxylic acid 2-tert-butyl ester
EINECS	Contact for details

Quality Control

Our 6-Bromo-3,4-Dihydro-1H-Isoquinoline-1,2-Dicarboxylic Acid 2-tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed when not in use to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.