Description

Ethyl 2-(4-Chloro-Phenyl)-6-Fluoro-1,2,3,4-Tetrahydro-Isoquinoline-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate of significant importance in modern drug discovery and development. This compound serves as a critical building block for the synthesis of novel therapeutic agents, particularly those targeting central nervous system and cardiovascular disorders. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in producing active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel tetrahydroisoquinoline-based active pharmaceutical ingredients (APIs).
• Drug Discovery Research: Used in medicinal chemistry programs for structure-activity relationship (SAR) studies and lead optimization.
• Neurological & Psychiatric Drug Development: Building block for potential therapeutics targeting receptors in the central nervous system.
• Cardiovascular Agent Synthesis: Intermediate in the development of compounds with potential vasodilatory or antihypertensive activity.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.
• Academic & Institutional Research: Used in university and institutional labs for pharmacological and chemical research.
• Process Chemistry Development: Serves as a standard for scaling up and optimizing synthetic routes in pilot plants.
• Reference Standard: High-purity material for analytical method development and quality control in API manufacturing.

Basic Information

Product Name	Ethyl 2-(4-Chloro-Phenyl)-6-Fluoro-1,2,3,4-Tetrahydro-Isoquinoline-1-Carboxylate
CAS No.	1260638-08-1
Molecular Formula	C18H17ClFNO2
Molecular Weight	333.79 g/mol
Synonyms	Ethyl 2-(4-chlorophenyl)-6-fluoro-1,2,3,4-tetrahydroisoquinoline-1-carboxylate; 1-Carbethoxy-2-(4-chlorophenyl)-6-fluoro-1,2,3,4-tetrahydroisoquinoline; 6-Fluoro-2-(4-chlorophenyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxylic Acid Ethyl Ester; 1260638-08-1; 2-(4-Chlorophenyl)-6-fluoro-1,2,3,4-tetrahydro-1-isoquinolinecarboxylic Acid Ethyl Ester; 1,2,3,4-Tetrahydro-2-(4-chlorophenyl)-6-fluoro-1-isoquinolinecarboxylic Acid Ethyl Ester
EINECS	Contact for details

Quality Control

Our Ethyl 2-(4-Chloro-Phenyl)-6-Fluoro-1,2,3,4-Tetrahydro-Isoquinoline-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with ICH guidelines and supports development under cGMP standards for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The container should be kept tightly sealed in a dry environment to minimize exposure to moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.