Description

2-(4-Fluoro-Phenyl)-6-Chloro-1,2,3,4-Tetrahydro-Isoquinoline-1-Carboxylic Acid is a high-purity, synthetically derived organic compound serving as a critical building block in advanced pharmaceutical research and development. Its unique molecular scaffold, featuring a tetrahydroisoquinoline core with fluorine and chlorine substituents, makes it a valuable intermediate for creating novel active pharmaceutical ingredients (APIs) with targeted biological activity. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to develop new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of novel drug candidates, particularly in central nervous system (CNS) and oncology research.
• Active Pharmaceutical Ingredient (API) Synthesis: Used in multi-step synthetic routes to construct complex molecular architectures for potential APIs.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Agrochemical Intermediate: Potential use in the synthesis of advanced herbicides or pesticides due to its halogenated aromatic structure.
• Fine Chemical Synthesis: Employed in custom synthesis and contract manufacturing for specialized, high-value chemical products.
• Reference Standard: Can be supplied as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	2-(4-Fluoro-Phenyl)-6-Chloro-1,2,3,4-Tetrahydro-Isoquinoline-1-Carboxylic Acid
CAS No.	1260637-82-8
Molecular Formula	C₁₆H₁₃ClFNO₂
Molecular Weight	305.73 g/mol
Synonyms	6-Chloro-2-(4-fluorophenyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid; 2-(4-Fluorophenyl)-6-chloro-1,2,3,4-tetrahydro-1-isoquinolinecarboxylic acid; 1,2,3,4-Tetrahydro-6-chloro-2-(4-fluorophenyl)-1-isoquinolinecarboxylic acid; CAS 1260637-82-8; 6-Chloro-2-(4-fluorophenyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxylate; 2-(p-Fluorophenyl)-6-chloro-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid
EINECS	Contact for details

Quality Control

Our 2-(4-Fluoro-Phenyl)-6-Chloro-1,2,3,4-Tetrahydro-Isoquinoline-1-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing all specifications and test results are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.