Description

6-Chloro-2-(2,4-Dichloro-Phenyl)-1,2,3,4-Tetrahydro-Isoquinoline-1-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate with the CAS registry number 1260637-75-9. This compound is a critical building block in modern organic synthesis, valued for its complex, functionalized isoquinoline core which serves as a key scaffold in medicinal chemistry. It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and anti-infective therapeutic areas.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of novel drug candidates targeting specific biological pathways.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• API Development: Serves as a critical building block in the production route for potential Active Pharmaceutical Ingredients (APIs), especially in neurological and psychiatric drug development.
• Chemical Reference Standard: Employed as a high-purity analytical standard for method development, validation, and quality control in regulatory submissions.
• Organic Synthesis: Utilized in academic and industrial research for exploring new synthetic methodologies involving halogenated heterocycles.

Basic Information

Product Name	6-Chloro-2-(2,4-Dichloro-Phenyl)-1,2,3,4-Tetrahydro-Isoquinoline-1-Carboxylic Acid
CAS No.	1260637-75-9
Molecular Formula	C₁₆H₁₂Cl₃NO₂
Molecular Weight	364.63 g/mol
Synonyms	6-Chloro-2-(2,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid; 1,2,3,4-Tetrahydro-6-chloro-2-(2,4-dichlorophenyl)-1-isoquinolinecarboxylic acid; 1260637-75-9; 6-Chloro-2-(2,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-isoquinolinecarboxylic acid; Tetrahydroisoquinoline-1-carboxylic acid derivative; Chlorinated tetrahydroisoquinoline carboxylic acid
EINECS	Contact for details

Quality Control

Our production of 6-Chloro-2-(2,4-Dichloro-Phenyl)-1,2,3,4-Tetrahydro-Isoquinoline-1-Carboxylic Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We employ advanced analytical techniques including HPLC, GC, NMR, and MS to verify the chemical identity and meet the exacting standards required for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The compound may be light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.