Description

2-Cbz-6-Methoxy-3,4-Dihydro-1H-Isoquinoline-1-Carboxylic Acid is a key protected intermediate in organic synthesis, valued for its role in constructing complex nitrogen-containing heterocycles. This compound is essential for research and development chemists requiring high-purity building blocks for pharmaceutical and agrochemical discovery. It is primarily utilized by fine chemical manufacturers and R&D laboratories focused on developing new active pharmaceutical ingredients (APIs) and specialty chemicals.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of novel isoquinoline-based drug candidates, including potential central nervous system (CNS) agents and antimicrobials.
• Agrochemical Research: Used in the development of new pesticides and herbicides, leveraging the isoquinoline scaffold for biological activity.
• Peptidomimetics & PROTACs: Serves as a protected carboxylic acid component for constructing peptide-like molecules and Proteolysis Targeting Chimeras (PROTACs).
• Chemical Biology Probes: Employed in the creation of molecular probes to study enzyme function and biological pathways.
• Academic & Industrial R&D: A versatile starting material for methodological chemistry research and scale-up process development.
• Custom Synthesis: Used by contract research and manufacturing organizations (CROs/CMOs) for bespoke synthesis projects requiring specific chiral or functionalized intermediates.

Basic Information

Product Name	2-Cbz-6-Methoxy-3,4-Dihydro-1H-Isoquinoline-1-Carboxylic Acid
CAS No.	1260637-46-4
Molecular Formula	C19H19NO5
Molecular Weight	341.36 g/mol
Synonyms	1-Carboxy-2-(benzyloxycarbonyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline; 2-[(Benzyloxy)carbonyl]-6-methoxy-1,2,3,4-tetrahydro-1-isoquinolinecarboxylic Acid; 6-Methoxy-2-(Cbz)-1,2,3,4-tetrahydroisoquinoline-1-carboxylic Acid; 2-Cbz-6-MeO-Tic-OH; 2-(Benzyloxycarbonyl)-6-methoxy-3,4-dihydro-1H-isoquinoline-1-carboxylic Acid; 1,2,3,4-Tetrahydro-6-methoxy-2-[(phenylmethoxy)carbonyl]-1-isoquinolinecarboxylic Acid
EINECS	Contact for details

Quality Control

Our 2-Cbz-6-Methoxy-3,4-Dihydro-1H-Isoquinoline-1-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.