Description

Ethyl 2-(4-Fluoro-Phenyl)-6-Hydroxy-1,2,3,4-Tetrahydro-Isoquinoline-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its specific tetrahydroisoquinoline scaffold with a fluorine substituent. This compound is critical for research and development in medicinal chemistry, particularly in the synthesis of novel active pharmaceutical ingredients (APIs) targeting central nervous system and cardiovascular disorders. It is primarily sought by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the development of new therapeutic agents.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, particularly those with tetrahydroisoquinoline-based structures.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to develop new therapeutic molecules.
• API Synthesis: Serves as a precursor in the multi-step synthesis of complex Active Pharmaceutical Ingredients (APIs) for preclinical and clinical trials.
• Chemical Reference Standard: Employed as a high-purity analytical standard for method development and quality control in pharmaceutical analysis.
• Academic Research: Utilized in university and institutional labs for studying organic synthesis methodologies and heterocyclic chemistry.

Basic Information

Product Name	Ethyl 2-(4-Fluoro-Phenyl)-6-Hydroxy-1,2,3,4-Tetrahydro-Isoquinoline-1-Carboxylate
CAS No.	1260637-19-1
Molecular Formula	C18H18FNO3
Molecular Weight	315.34 g/mol
Synonyms	Ethyl 2-(4-fluorophenyl)-6-hydroxy-3,4-dihydro-1H-isoquinoline-1-carboxylate; 1(2H)-Isoquinolinecarboxylic acid, 3,4-dihydro-2-(4-fluorophenyl)-6-hydroxy-, ethyl ester; 2-(4-Fluorophenyl)-6-hydroxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid ethyl ester; 6-Hydroxy-2-(4-fluorophenyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid ethyl ester; Ethyl 6-hydroxy-2-(4-fluorophenyl)-1,2,3,4-tetrahydro-1-isoquinolinecarboxylate
EINECS	Contact for details

Quality Control

Our Ethyl 2-(4-Fluoro-Phenyl)-6-Hydroxy-1,2,3,4-Tetrahydro-Isoquinoline-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, IR, MS), to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider storage under an inert atmosphere to ensure maximum stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.