Description

(3R,4R)-Ethyl 3-(3-Bromo-4-Fluorophenyl)-1-Oxo-2-Propyl-1,2,3,4-Tetrahydroisoquinoline-4-Carboxylate is a high-purity chiral building block and advanced pharmaceutical intermediate. This compound is critical for the synthesis of complex, biologically active molecules, offering precise stereochemical control essential for modern drug development. It is primarily needed by research institutions and pharmaceutical companies engaged in the discovery and production of novel therapeutic agents, particularly within medicinal chemistry and process R&D.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of potential drug candidates, especially for central nervous system (CNS) or oncology targets.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization to explore new chemical entities.
• Process Chemistry Development: Serves as a critical starting material or intermediate for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions.
• Asymmetric Synthesis: Utilized in reactions requiring high enantiomeric excess due to its defined (3R,4R) stereochemistry.
• Reference Standard: Acts as an analytical standard for quality control and method validation in API (Active Pharmaceutical Ingredient) manufacturing.
• Custom Synthesis: A foundational component for contract research organizations (CROs) and CDMOs (Contract Development and Manufacturing Organizations) offering bespoke chemical services.

Basic Information

Product Name	(3R,4R)-Ethyl 3-(3-Bromo-4-Fluorophenyl)-1-Oxo-2-Propyl-1,2,3,4-Tetrahydroisoquinoline-4-Carboxylate
CAS No.	1260606-50-5
Molecular Formula	C21H21BrFNO3
Molecular Weight	434.30 g/mol
Synonyms	Ethyl (3R,4R)-3-(3-bromo-4-fluorophenyl)-1-oxo-2-propyl-1,2,3,4-tetrahydroisoquinoline-4-carboxylate; (3R,4R)-Ethyl 3-(3-Bromo-4-Fluorophenyl)-1-Oxo-2-Propyl-1,2,3,4-Tetrahydro-4-isoquinolinecarboxylate; 1260606-50-5; UNII-7B2F4C8F3W; SCHEMBL21824027; DTXSID60664669; AKOS040759232; ZINC000095409767
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Every batch is characterized using advanced analytical techniques including HPLC, NMR, and chiral analysis to confirm identity, purity, and enantiomeric excess. Certificates of Analysis (COA) detailing all specifications are available upon request. We adhere to a quality management system suitable for supplying materials for research and development under cGMP guidelines where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound may be sensitive to strong bases and fluorides; store away from such incompatible materials. For long-term storage, consider inert atmosphere conditions to ensure stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.