Description

(3R,4R)-Ethyl 3-(4-Bromo-2-Fluorophenyl)-1-Oxo-2-Propyl-1,2,3,4-Tetrahydroisoquinoline-4-Carboxylate is a high-purity, chiral synthetic intermediate of significant importance in advanced pharmaceutical research and development. Its value lies in its complex molecular architecture, which serves as a critical building block for the synthesis of novel, biologically active compounds. This product is essential for medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries, particularly those focused on central nervous system (CNS) and oncology drug discovery programs.

Application

• Pharmaceutical Intermediate: Key chiral precursor in the synthesis of potential drug candidates, especially for neurological and oncological targets.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes.
• Process Chemistry Development: Serves as a critical starting material for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions.
• Asymmetric Synthesis: Utilized in the development of stereoselective synthetic methodologies due to its defined (3R,4R) configuration.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method validation in API manufacturing.
• Custom Synthesis: Building block for the contract research and manufacturing (CRAM) sector to produce bespoke molecules for client projects.

Basic Information

Product Name	(3R,4R)-Ethyl 3-(4-Bromo-2-Fluorophenyl)-1-Oxo-2-Propyl-1,2,3,4-Tetrahydroisoquinoline-4-Carboxylate
CAS No.	1260606-41-4
Molecular Formula	C21H21BrFNO3
Molecular Weight	434.30 g/mol
Synonyms	Ethyl (3R,4R)-3-(4-Bromo-2-fluorophenyl)-1-oxo-2-propyl-1,2,3,4-tetrahydro-4-isoquinolinecarboxylate; (3R,4R)-3-(4-Bromo-2-fluorophenyl)-2-propyl-1,2,3,4-tetrahydro-1-oxo-4-isoquinolinecarboxylic acid ethyl ester; 1260606-41-4; UNII-9G9N1I8V8M; 9G9N1I8V8M; SCHEMBL21824027; DTXSID60636669; AKOS040759232.
EINECS	Contact for details

Quality Control

Our (3R,4R)-Ethyl 3-(4-Bromo-2-Fluorophenyl)-1-Oxo-2-Propyl-1,2,3,4-Tetrahydroisoquinoline-4-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and NMR for structural confirmation, to ensure compliance with stringent research-grade specifications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. The compound is light-sensitive and should be handled under appropriate conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.