Description

tert-Butyl 8-Bromo-4,5-Dihydroazepino[4,3-B]Indole-2(1H,3H,6H)-Carboxylate CAS NO 1260494-16-3 is a high-purity, advanced pharmaceutical intermediate featuring a complex, fused heterocyclic structure. This compound is of significant value in medicinal chemistry for its role as a key building block in the synthesis of novel, biologically active molecules. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, particularly within oncology and central nervous system (CNS) drug discovery pipelines.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of potential drug candidates targeting specific biological pathways.
• Medicinal Chemistry Research: Used extensively in structure-activity relationship (SAR) studies to optimize the potency and selectivity of lead compounds.
• Proteolysis Targeting Chimera (PROTAC) Development: Its bromo-functionalized indole-azepine scaffold can be utilized to construct linkers or warheads for targeted protein degradation technologies.
• Kinase Inhibitor Synthesis: Acts as a core structural motif for the development of novel kinase inhibitors due to its privileged heterocyclic architecture.
• Chemical Biology Probes: Employed in the creation of specialized molecular probes for studying enzyme function and cellular processes.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting pharmaceutical R&D and scale-up activities.

Basic Information

Item	Details
Product Name	tert-Butyl 8-Bromo-4,5-Dihydroazepino[4,3-B]Indole-2(1H,3H,6H)-Carboxylate
CAS No.	1260494-16-3
Molecular Formula	C17H21BrN2O2
Molecular Weight	365.27 g/mol
Synonyms	8-Bromo-1,2,3,4,5,6-hexahydroazepino[4,3-b]indole-2-carboxylic acid tert-butyl ester; tert-Butyl 8-bromo-1,2,3,4,5,6-hexahydroazepino[4,3-b]indole-2-carboxylate; 8-Bromo-4,5-dihydro-1H-azepino[4,3-b]indole-2(3H,6H)-carboxylic acid, 1,1-dimethylethyl ester; 1260494-16-3; 8-Bromo-1,2,3,4,5,6-hexahydroazepino[4,3-b]indole-2-carboxylic acid 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 8-Bromo-4,5-Dihydroazepino[4,3-B]Indole-2(1H,3H,6H)-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) detailing HPLC purity, NMR confirmation, and other critical parameters are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The compound may be sensitive to moisture and should be handled under inert atmosphere for long-term storage.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.