Description

5-Chloro-3-Iodo-7-Azaindole-6-Carboxylic Acid is a high-value, halogenated heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in its unique molecular scaffold, which serves as a versatile precursor for constructing complex pharmacophores and functional materials. This compound is primarily sought by research and development chemists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, including the development of kinase inhibitors and other targeted therapeutics.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel small-molecule drug candidates, particularly in oncology and antiviral research.
• Kinase Inhibitor Development: Used as a core scaffold or substituent in the design and optimization of potent and selective kinase inhibitors.
• Agrochemical Research: Serves as a building block for creating new active ingredients with herbicidal or pesticidal properties.
• Chemical Biology Probes: Utilized in the development of molecular probes for studying enzyme function and cellular signaling pathways.
• Material Science: Potential precursor for organic electronic materials due to its electron-deficient azaindole core and halogen substituents.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research institutions for bespoke synthetic routes and library production.

Basic Information

Product Name	5-Chloro-3-Iodo-7-Azaindole-6-Carboxylic Acid
CAS No.	1260386-87-5
Molecular Formula	C8H4ClIN2O2
Molecular Weight	322.48 g/mol
Synonyms	5-Chloro-3-iodo-1H-pyrrolo[2,3-b]pyridine-6-carboxylic acid; 3-Iodo-5-chloro-7-azaindole-6-carboxylic acid; 6-Carboxy-5-chloro-3-iodo-7-azaindole; 1H-Pyrrolo[2,3-b]pyridine-6-carboxylic acid, 5-chloro-3-iodo-; 5-Chloro-3-iodo-1H-pyrrolo[2,3-b]pyridine-6-carboxylic acid (CAS 1260386-87-5)
EINECS	Contact for details

Quality Control

Our 5-Chloro-3-Iodo-7-Azaindole-6-Carboxylic Acid is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for demanding research and development applications. We provide comprehensive analytical documentation, including HPLC, NMR, and mass spectrometry data. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for every batch upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.