Description

4-Nitro-1H-Indazole-3-Carbonitrile is a high-purity, advanced pharmaceutical intermediate characterized by its nitro-substituted indazole core. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of novel, targeted therapeutic agents. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of kinase inhibitors and other small-molecule drugs, where its specific scaffold provides a key structural motif.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potent kinase inhibitors for oncology and inflammatory disease research.
• Medicinal Chemistry Research: Serves as a versatile scaffold for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• Chemical Biology Probes: Used in the development of selective chemical probes to study specific enzyme functions and biological pathways.
• Agrochemical Research: Potential intermediate in the research and development of new active ingredients for crop protection.
• Organic Synthesis Building Block: Employed in complex multi-step organic syntheses due to its reactive nitro and nitrile functional groups.

Basic Information

Product Name	4-Nitro-1H-Indazole-3-Carbonitrile
CAS No.	1260386-34-2
Molecular Formula	C8H4N4O2
Molecular Weight	188.14 g/mol
Synonyms	4-Nitro-1H-indazole-3-carbonitrile; 1H-Indazole-3-carbonitrile, 4-nitro-; 4-Nitroindazole-3-carbonitrile; 3-Cyano-4-nitro-1H-indazole; 4-Nitro-1H-indazol-3-yl cyanide
EINECS	Contact for details

Quality Control

Our 4-Nitro-1H-Indazole-3-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). The compound should be considered moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.