Description

1→4-β-Oleandropyranosyl-11-o-Isobutyryl-12-o-Acetyltenacigenin B is a high-purity, structurally defined cardiac glycoside derivative, offering a critical reference standard for advanced pharmaceutical research and development. This compound is essential for ensuring analytical accuracy and quality control in the study of bioactive natural products and their synthetic analogs. It is primarily utilized by research institutions, pharmaceutical companies, and analytical laboratories focused on cardiovascular drug discovery, phytochemical analysis, and metabolic pathway studies.

Application

• Pharmaceutical Reference Standard: Serves as a certified primary standard for the qualitative and quantitative analysis of tenacigenin B derivatives in drug substances and finished products.
• Cardiovascular Research: Used as a key biochemical tool in in vitro and in vivo studies to investigate the mechanisms of cardiac glycosides and their effects on ion channels.
• Natural Product Chemistry: Acts as a critical marker compound for the isolation, identification, and purity assessment of related compounds from plant extracts like Marsdenia tenacissima.
• Metabolite Studies: Employed in pharmacokinetic and metabolic stability studies to identify and quantify potential metabolites of related therapeutic agents.
• Process Development & Validation: Used to develop and validate analytical methods (HPLC, LC-MS) for manufacturing process control of related active pharmaceutical ingredients (APIs).
• Biological Screening: Utilized in high-throughput screening assays to evaluate the biological activity and potency of novel cardiac glycoside analogs.

Basic Information

Product Name	1→4-β-Oleandropyranosyl-11-o-Isobutyryl-12-o-Acetyltenacigenin B
CAS No.	1260252-18-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Tenacigenin B 11-O-isobutyryl-12-O-acetyl-4-O-oleandropyranoside; 11-O-Isobutyryl-12-O-acetyltenacigenin B 4-O-β-oleandropyranoside; (11β,12β)-11,12-Bis(acetyloxy)-3,14-dihydroxy-19-oxo-5β-card-20(22)-enolide 3-[4,6-dideoxy-3-O-methyl-β-D-xylo-hexopyranoside]; CAS 1260252-18-3; Tenacissoside I derivative; Marsdenia tenacissima glycoside derivative
EINECS	Contact for details

Quality Control

Every batch of 1→4-β-Oleandropyranosyl-11-o-Isobutyryl-12-o-Acetyltenacigenin B is manufactured and analyzed under strict quality management systems. Our products undergo rigorous identity confirmation, purity analysis, and impurity profiling using advanced chromatographic and spectroscopic techniques to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing batch-specific results for identity, assay, purity, and residual solvents is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the certificate of analysis. This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum corresponds to reference standard
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0% (on dried basis)
Loss on Drying	≤ 2.0%
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.