Description

Trans 4-Dimethylaminocrotonic Acid-D6 Methyl Ester is a deuterium-labeled derivative of a key crotonic acid ester, serving as a critical stable isotope-labeled intermediate for advanced research and development. Its primary value lies in its use as an internal standard in quantitative mass spectrometry, enabling precise and accurate analytical measurements. This compound is essential for scientists and manufacturers in the pharmaceutical, agrochemical, and analytical chemistry sectors who require high-fidelity isotopic tracers for metabolic studies, pharmacokinetic profiling, and method development.

Application

• Internal Standard for LC-MS/MS: Used as a deuterated internal standard in liquid chromatography-tandem mass spectrometry for the quantitative analysis of its non-labeled counterpart or related metabolites.
• Pharmaceutical Research: Critical for drug metabolism and pharmacokinetics (DMPK) studies, aiding in the accurate tracing and quantification of active pharmaceutical ingredients.
• Metabolic Pathway Tracing: Enables detailed investigation of biochemical pathways in both in vitro and in vivo systems due to its isotopic label.
• Analytical Method Development: Supports the validation and calibration of sensitive analytical methods in compliance with regulatory guidelines (e.g., FDA, ICH).
• Chemical Synthesis Intermediate: Acts as a specialized building block for the synthesis of more complex deuterium-labeled target molecules.
• Reference Material: Serves as a high-purity certified reference material (CRM) for quality control laboratories.

Basic Information

Product Name	Trans 4-Dimethylaminocrotonic Acid-D6 Methyl Ester
CAS No.	1259680-82-4
Molecular Formula	C7D6H7NO2
Molecular Weight	158.21 g/mol
Synonyms	(E)-4-(Dimethylamino)but-2-enoic-2,3,4,5,6,6-d6 Acid Methyl Ester; Methyl (E)-4-(dimethylamino)but-2-enoate-2,3,4,5,6,6-d6; trans-4-(N,N-Dimethylamino)crotonic Acid-d6 Methyl Ester; 4-Dimethylaminocrotonic Acid Methyl Ester-d6; Deuterated Trans-4-Dimethylaminocrotonate Methyl Ester; Methyl Trans-4-(Dimethylamino)crotonate-d6; [D6]-Trans-4-Dimethylaminocrotonic Acid Methyl Ester
EINECS	Contact for details

Quality Control

Every batch of Trans 4-Dimethylaminocrotonic Acid-D6 Methyl Ester is manufactured and analyzed under strict quality systems. We guarantee high chemical and isotopic purity, supported by comprehensive analytical data including NMR (¹H, ¹³C), mass spectrometry, and HPLC. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, isotopic enrichment, and confirming the absence of significant impurities. Our quality commitment ensures reliability for your most sensitive analytical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.