Description

Trans 4-Dimethylaminocrotonic Acid-D6 Hydrochloride is a high-purity, deuterium-labeled derivative of a key crotonic acid intermediate, essential for advanced research and development. Its primary value lies in its utility as a stable isotope-labeled internal standard for precise quantitative analysis in mass spectrometry. This compound is critically needed by pharmaceutical R&D laboratories, analytical chemistry service providers, and academic institutions engaged in metabolic studies, pharmacokinetic research, and method development.

Application

• Internal Standard for LC-MS/MS: Used as a deuterated internal standard for the accurate quantification of its non-labeled counterpart or related metabolites in complex biological matrices like plasma, serum, and urine.
• Pharmaceutical Research: Facilitates drug metabolism and pharmacokinetics (DMPK) studies, enabling precise tracking of drug candidate absorption, distribution, metabolism, and excretion (ADME).
• Analytical Method Development: Serves as a critical reference material for developing and validating highly sensitive and specific bioanalytical assays in compliance with GLP guidelines.
• Metabolite Identification: Aids in the identification and structural elucidation of drug metabolites by providing a known mass shift for comparative spectral analysis.
• Isotope Dilution Mass Spectrometry (IDMS): Employed in high-accuracy quantification techniques where the labeled analog compensates for sample preparation losses and ionization variability.
• Chemical Synthesis Intermediate: Acts as a specialized, labeled building block for the synthesis of more complex deuterated molecules for research purposes.

Basic Information

Product Name	Trans 4-Dimethylaminocrotonic Acid-D6 Hydrochloride
CAS No.	1259519-59-9
Molecular Formula	C6D6H3NO2 • HCl
Molecular Weight	~194.66 g/mol (for deuterated form)
Synonyms	(E)-4-(Dimethylamino)but-2-enoic-2,3,4,5,6,6-d6 Acid Hydrochloride; 4-(N,N-Dimethylamino)crotonic Acid-d6 HCl; (2E)-4-(Dimethylamino)-2-butenoic-2,3,4,5,6,6-d6 Acid Hydrochloride; trans-4-(Dimethylamino)crotonic Acid-d6 Hydrochloride; DMA-Crotonic Acid-d6 HCl; Deuterated Trans-4-Dimethylaminocrotonic Acid HCl; 1259519-59-9 (CAS); Labeled Crotonic Acid Derivative
EINECS	Contact for details

Quality Control

Every batch of Trans 4-Dimethylaminocrotonic Acid-D6 Hydrochloride is manufactured and analyzed under strict quality systems. We guarantee high chemical purity and isotopic enrichment, supported by comprehensive analytical data including NMR (1H, 13C), Mass Spectrometry, and HPLC. Certificates of Analysis (COA) detailing purity, isotopic purity (D-enrichment), and all relevant specifications are provided and available upon request to ensure full traceability and compliance with your research protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a cool, dry place. This compound is hygroscopic (moisture-sensitive); ensure the container is sealed under inert atmosphere if specified and avoid exposure to humid conditions during handling. For long-term storage, consider desiccated conditions at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.