Description

(E)-4-[Bis(Trideuteriomethyl)Amino]-n-[4-[3-Chloro-4-(Pyridin-2-Ylmethoxy)Anilino]-3-Cyano-7-Ethoxyquinolin-6-Yl]But-2-Enamide is a deuterated, high-purity chemical intermediate of significant importance in advanced pharmaceutical research and development. Its core value lies in its role as a deuterium-labeled analog of kinase inhibitor scaffolds, enabling critical studies in drug metabolism, pharmacokinetics (DMPK), and bioanalytical method development. This compound is essential for pharmaceutical companies, contract research organizations (CROs), and academic research institutions focused on oncology and targeted therapy discovery.

Application

• Internal Standard for LC-MS/MS Analysis: Primary application as a stable, deuterium-labeled internal standard for the quantitative bioanalysis of parent drug molecules in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used in mass spectrometry to trace metabolic pathways, assess stability, and determine pharmacokinetic parameters without isotopic interference.
• Preclinical and Clinical Research: Supports the development and validation of analytical methods for novel kinase inhibitors in various stages of the drug pipeline.
• Isotope Dilution Mass Spectrometry (IDMS): Enables highly accurate and precise quantification in complex samples, crucial for meeting regulatory standards in drug development.
• Chemical Reference Standard: Serves as a certified reference material (CRM) for quality control and assurance in pharmaceutical manufacturing.
• Mechanistic Biochemical Research: A tool for studying enzyme inhibition mechanisms and binding interactions in biochemical assays.

Basic Information

Product Name	(E)-4-[Bis(Trideuteriomethyl)Amino]-n-[4-[3-Chloro-4-(Pyridin-2-Ylmethoxy)Anilino]-3-Cyano-7-Ethoxyquinolin-6-Yl]But-2-Enamide
CAS No.	1259519-18-0
Molecular Formula	C₃₃H₂₉D₆ClN₆O₃
Molecular Weight	605.18 g/mol (for monoisotopic mass)
Synonyms	Deuterated Kinase Inhibitor Intermediate; d6-Labeled Anilinoquinoline Derivative; (E)-4-[Bis(Trideuteromethyl)Amino]-N-[4-[[3-Chloro-4-(2-Pyridinylmethoxy)Phenyl]Amino]-3-Cyano-7-Ethoxy-6-Quinolinyl]-2-Butenamide; 4-[Bis(Trideuteriomethyl)Amino]-N-[4-[[3-Chloro-4-(2-Pyridinylmethoxy)Phenyl]Amino]-3-Cyano-7-Ethoxy-6-Quinolinyl]-2-Butenamide, (2E)-; Deuterated Analog of Foretinib/Linibinib related compound; 1259519-18-0; API Deuterated Intermediate
EINECS	Contact for details

Quality Control

Our deuterated chemical intermediates are produced under strict quality management systems. Each batch of (E)-4-[Bis(Trideuteriomethyl)Amino]-n-[4-[3-Chloro-4-(Pyridin-2-Ylmethoxy)Anilino]-3-Cyano-7-Ethoxyquinolin-6-Yl]But-2-Enamide undergoes comprehensive analysis to ensure high chemical purity, isotopic purity (deuterium incorporation), and structural identity. Certificates of Analysis (COA) are provided, detailing results from HPLC, NMR (¹H, ¹³C), and Mass Spectrometry. We support compliance with ICH Q7 and cGMP guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or CoA. The product is light-sensitive (store away from light). For long-term storage, consider desiccation to maintain stability. Keep container tightly sealed in a dry and well-ventilated place.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (d6, by MS)	≥ 98.0 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.