Description

17,17-Ethylenedioxy-1,3,5(10)-Estratriene-3,16α-Diol-D5 is a deuterated derivative of a key estradiol intermediate, featuring a ketal-protected 17-keto group. This compound is a critical stable isotope-labeled standard used for precise quantification and metabolic pathway tracing in analytical research. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and manufacturers of diagnostic kits for method development and validation in bioanalytical studies.

Application

• Internal Standard for LC-MS/MS: Serves as a high-purity, isotopically labeled internal standard for the accurate quantification of estradiol and related metabolites in complex biological matrices like plasma, serum, and urine.
• Metabolic Pathway Research: Used in pharmacokinetic (PK) and pharmacodynamic (PD) studies to trace and elucidate the metabolic fate of steroid hormones.
• Diagnostic Assay Development: Essential for calibrating and validating high-sensitivity clinical diagnostic assays, including those for endocrine function and hormone-related disorders.
• Pharmaceutical Impurity Profiling: Aids in the identification and quantification of process-related impurities and degradants during the synthesis of steroidal active pharmaceutical ingredients (APIs).
• Forensic and Anti-Doping Analysis: Employed as a reference standard in forensic toxicology and sports anti-doping controls for the detection of exogenous steroid administration.
• Academic Research: Supports fundamental research in endocrinology, steroid biochemistry, and hormone-dependent disease mechanisms.

Basic Information

Product Name	17,17-Ethylenedioxy-1,3,5(10)-Estratriene-3,16α-Diol-D5
CAS No.	1259370-24-5
Molecular Formula	C20H21D5O4
Molecular Weight	335.44 g/mol
Synonyms	16α-Hydroxy-17,17-ethylenedioxyestra-1,3,5(10)-triene-3-ol-d5; Estra-1,3,5(10)-triene-3,16α-diol, 17,17-ethylenedioxy-, (16α)-, pentadeuterio-; Deuterated 17,17-Ethylenedioxy Estradiol Intermediate; [D5]-17,17-Ethylenedioxyestradiol; 3,16α-Dihydroxy-17,17-ethylenedioxyestra-1,3,5(10)-triene-d5; Estradiol-17,17-ethylenedioxy ketal-d5; 16α-Hydroxy-3-hydroxyestra-1,3,5(10)-trien-17-one ethylene ketal-d5
EINECS	Contact for details

Quality Control

Every batch of 17,17-Ethylenedioxy-1,3,5(10)-Estratriene-3,16α-Diol-D5 is manufactured and analyzed under strict quality systems. We guarantee high chemical and isotopic purity to meet the exacting demands of analytical reference standard applications. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with industry standards. Certificates of Analysis (COA) detailing batch-specific purity, isotopic enrichment, and impurity profiles are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at 2-8°C to ensure maximum stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (MS)	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.