Description

7-Chloro-1,2,3,4-Tetrahydroisoquinolin-6-Amine is a high-purity, advanced pharmaceutical intermediate belonging to the tetrahydroisoquinoline class of compounds. This compound matters as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders. Pharmaceutical research and development organizations, as well as fine chemical manufacturers, require this material for its precise molecular structure, which enables the creation of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of new drug candidates, especially for neurological and psychiatric applications.
• Organic Synthesis Building Block: Used in medicinal chemistry for constructing complex heterocyclic frameworks and exploring structure-activity relationships (SAR).
• Research & Development (R&D): Essential for academic and industrial research laboratories focusing on neuropharmacology and novel therapeutic pathways.
• Active Pharmaceutical Ingredient (API) Synthesis: Employed in the multi-step synthesis of potential APIs targeting specific receptors in the CNS.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production of clinical trial materials.

Basic Information

Product Name	7-Chloro-1,2,3,4-Tetrahydroisoquinolin-6-Amine
CAS No.	1259326-52-7
Molecular Formula	C9H11ClN2
Molecular Weight	182.65 g/mol
Synonyms	6-Amino-7-chloro-1,2,3,4-tetrahydroisoquinoline; 7-Chloro-6-amino-1,2,3,4-tetrahydroisoquinoline; 1,2,3,4-Tetrahydro-7-chloroisoquinolin-6-amine; 7-Chloro-1,2,3,4-tetrahydro-6-isoquinolinamine; 7-Chloro-THIQ-6-amine; 7-Cl-THIQ-6-NH2
EINECS	Contact for details

Quality Control

Our 7-Chloro-1,2,3,4-Tetrahydroisoquinolin-6-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D and synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.