Description

2-(3-(Trifluoromethyl)-4,5,6,7-Tetrahydroindazol-1-Yl)-n-(Prop-2-Ynyl)Acetamide is a high-purity, advanced pharmaceutical intermediate featuring a unique trifluoromethylated tetrahydroindazole scaffold. This compound matters for its critical role as a key building block in the synthesis of novel, potent small-molecule therapeutics, particularly in oncology and targeted disease areas. Pharmaceutical R&D teams and fine chemical manufacturers need this material to develop next-generation drug candidates where the trifluoromethyl group is essential for enhancing metabolic stability, lipophilicity, and binding affinity.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially kinase inhibitors and other targeted therapies.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) around the indazole core.
• Preclinical Drug Development: Serves as a key starting material (KSM) or advanced intermediate in the scale-up synthesis of candidate drugs for toxicology and clinical studies.
• Chemical Biology Probes: Utilized in the development of chemical probes to study specific biological pathways and protein functions.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting pharmaceutical companies in outsourced drug discovery and development programs.
• Academia & Institutional Research: Employed in university and research institute labs for fundamental studies in organic synthesis and drug design methodologies.

Basic Information

Product Name	2-(3-(Trifluoromethyl)-4,5,6,7-Tetrahydroindazol-1-Yl)-n-(Prop-2-Ynyl)Acetamide
CAS No.	1258652-77-5
Molecular Formula	C15H16F3N3O
Molecular Weight	311.31 g/mol
Synonyms	N-(Prop-2-yn-1-yl)-2-[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]acetamide; 2-(3-(Trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-N-(prop-2-yn-1-yl)acetamide; 1H-Indazole-1-acetamide, N-2-propynyl-4,5,6,7-tetrahydro-3-(trifluoromethyl)-; CAS 1258652-77-5; Trifluoromethyl Tetrahydroindazole Acetamide Derivative; Propargyl-linked Indazole Acetamide
EINECS	Contact for details

Quality Control

Every batch of 2-(3-(Trifluoromethyl)-4,5,6,7-Tetrahydroindazol-1-Yl)-n-(Prop-2-Ynyl)Acetamide is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency meet the exacting standards required for pharmaceutical R&D. Certificates of Analysis (COA) with full analytical data are provided for each lot, and custom synthesis to meet specific purity or impurity profile requirements is available.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.