Description

11-Deoxycortisol-[D5] is a high-purity, stable isotope-labeled analog of the endogenous steroid hormone 11-deoxycortisol. This compound is an essential internal standard for the precise quantification of 11-deoxycortisol in complex biological matrices using mass spectrometry. It is primarily used by clinical research laboratories, pharmaceutical R&D teams, and diagnostic manufacturers to ensure analytical accuracy and reproducibility in steroid profiling and endocrine disorder studies.

Application

• Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) Internal Standard: Critical for the accurate quantification of 11-deoxycortisol in clinical assays for diagnosing disorders of the hypothalamic-pituitary-adrenal (HPA) axis.
• Biomarker Research and Validation: Used in research studies investigating steroidogenesis, adrenal function, and conditions like congenital adrenal hyperplasia (CAH).
• Pharmaceutical Metabolism and Pharmacokinetics (PK) Studies: Employed as a stable isotope tracer to study the metabolic pathways and clearance of corticosteroid-based therapeutics.
• Quality Control in Diagnostic Kit Manufacturing: Serves as a reference material in the production and calibration of in-vitro diagnostic (IVD) kits for hormone testing.
• Endocrinology and Clinical Chemistry: Supports method development and routine testing in hospital and reference laboratories for precise steroid hormone analysis.

Basic Information

Product Name	11-Deoxycortisol-[D5]
CAS No.	1258063-56-7
Molecular Formula	C21H25D5O4
Molecular Weight	347.48 g/mol
Synonyms	17α,21-Dihydroxypregn-4-ene-3,20-dione-[17,21,21,21,21-D5]; Cortexolone-[D5]; Reichstein's Substance S-[D5]; 11-Deoxycortisol d5; 11-Deoxyhydrocortisone-[D5]; (11-Deoxy)-(17,21,21,21,21-D5)cortisol; 17α-Hydroxyprogesterone-[21,21,21-D5]
EINECS	Contact for details

Quality Control

Every batch of 11-Deoxycortisol-[D5] is manufactured and analyzed under strict quality systems. We provide comprehensive analytical data to support its use in regulated environments. Certificates of Analysis (COA) are supplied with each shipment, detailing results for identity, chemical purity, isotopic purity, and solvent content as determined by advanced techniques including NMR, HPLC, and LC-MS. Our quality commitment ensures reliable and reproducible performance as a critical reference material.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98 atom % D
Chemical Purity	≥ 95%
Solvent Content (Residual Solvents)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.