Description

4-Methyl-5-(trifluoromethyl)thiazol-2-amine is a high-value, fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in the unique combination of the electron-withdrawing trifluoromethyl group and the versatile 2-aminothiazole scaffold, enabling the development of novel compounds with enhanced properties. This intermediate is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors, anti-infectives, and central nervous system (CNS) agents.
• Agrochemical Research: Used in the synthesis of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group can improve metabolic stability and bioavailability.
• Material Science Precursor: Serves as a building block for specialty chemicals, including ligands for catalysis and monomers for advanced polymers.
• Chemical Biology Probe Development: Utilized in the design and synthesis of molecular probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in client-specific synthesis projects.

Basic Information

Product Name	4-Methyl-5-(Trifluoromethyl)Thiazol-2-Amine
CAS No.	1257329-71-7
Molecular Formula	C5H5F3N2S
Molecular Weight	182.17 g/mol
Synonyms	2-Amino-4-methyl-5-(trifluoromethyl)thiazole; 5-(Trifluoromethyl)-4-methyl-1,3-thiazol-2-amine; 4-Methyl-5-trifluoromethyl-2-aminothiazole; 4-Methyl-5-(trifluoromethyl)-2-thiazolamine; 2-Thiazolamine, 4-methyl-5-(trifluoromethyl)-; 4-Methyl-5-trifluoromethylthiazol-2-ylamine
EINECS	Contact for details

Quality Control

Every batch of 4-Methyl-5-(trifluoromethyl)thiazol-2-amine is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the precise requirements of research and development applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.