Description

n-Hexanoylglycine-D2 is a deuterated derivative of the endogenous metabolite hexanoylglycine, specifically labeled with two deuterium atoms. This compound is of significant value as a high-purity internal standard for quantitative mass spectrometry-based metabolomic and biomarker studies, ensuring analytical accuracy and reproducibility. It is primarily required by pharmaceutical R&D laboratories, clinical research organizations, and diagnostic developers focusing on inborn errors of metabolism, such as medium-chain acyl-CoA dehydrogenase (MCAD) deficiency.

Application

• Internal Standard for LC-MS/MS: Critical for the precise quantification of hexanoylglycine in complex biological matrices like urine, plasma, and serum.
• Metabolomics Research: Used in stable isotope dilution assays to study metabolic pathways and fluctuations in disease states.
• Newborn Screening & Diagnostics: Essential component in assay kits and methods for the accurate diagnosis of disorders of fatty acid oxidation.
• Biomarker Discovery & Validation: Enables reliable measurement of hexanoylglycine as a potential biomarker for various metabolic and hepatic conditions.
• Pharmaceutical Development: Employed in drug metabolism and pharmacokinetics (DMPK) studies to track metabolite profiles.
• Quality Control Reference: Serves as a certified reference material (CRM) for calibrating analytical instruments and validating laboratory methods.

Basic Information

Product Name	n-Hexanoylglycine-D2
CAS No.	1256842-52-0
Molecular Formula	C8H13D2NO3
Molecular Weight	175.21 g/mol (for deuterated form)
Synonyms	Hexanoylglycine-d2; N-(1-Oxohexyl)glycine-d2; 2-[(1-Oxohexyl)amino]acetic-2,2-d2 acid; N-Caproylglycine-d2; Caproylglycine-d2; Hexanoylaminoacetic-2,2-d2 acid; Deuterated Hexanoylglycine; [2,2-2H2]-Hexanoylglycine
EINECS	Contact for details

Quality Control

Our n-Hexanoylglycine-D2 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for analytical applications. Each batch is characterized by NMR, HPLC, and mass spectrometry to confirm structure, chemical purity, and deuterium incorporation. A comprehensive Certificate of Analysis (COA) detailing purity, isotopic enrichment, and analytical results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. The product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.