Description

n-Propionylglycine-2,2-D2 is a stable isotope-labeled analog of propionylglycine, specifically deuterated at the 2,2 positions of the glycine moiety. This precise labeling makes it an indispensable internal standard and tracer in advanced analytical and metabolic research. It is primarily utilized by scientists and manufacturers in the fields of pharmaceutical development, clinical diagnostics, and metabolic pathway analysis. The compound enables highly accurate quantification and mechanistic studies in complex biological matrices.

Application

• Internal Standard for LC-MS/MS: Used for the precise quantification of propionylglycine and related metabolites in bioanalytical assays.
• Metabolic Tracer Studies: Investigates propionate metabolism and related disorders, such as propionic acidemia, in research settings.
• Pharmaceutical R&D: Supports drug metabolism and pharmacokinetics (DMPK) studies for compounds affecting amino acid metabolism.
• Clinical Diagnostics: Enhances the accuracy of newborn screening and diagnostic tests for inborn errors of metabolism.
• Biomarker Research: Aids in the discovery and validation of disease biomarkers linked to mitochondrial function and energy metabolism.
• Stable Isotope Labeling: Serves as a building block for synthesizing more complex deuterated molecules for research.

Basic Information

Product Name	n-Propionylglycine-2,2-D2
CAS No.	1256842-51-9
Molecular Formula	C5H7D2NO3
Molecular Weight	133.15 g/mol (for deuterated form)
Synonyms	Propionylglycine-2,2-d2; N-Propionyl-d2-glycine; 2,2-Dideuterio-N-propionylglycine; (2,2-Dideuterioglycyl)propanoic acid; Propanoic acid, 2,2-dideuterio-2-[(1-oxopropyl)amino]-; Deuterated Propionylglycine; N-(Propanoyl)glycine-2,2-D2; Stable Isotope-Labeled Propionylglycine
EINECS	Contact for details

Quality Control

Our n-Propionylglycine-2,2-D2 is produced under strict quality management systems to ensure exceptional isotopic and chemical purity for research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment (D atom %), chemical purity by HPLC, and identity confirmation by NMR and MS. We adhere to relevant standards for high-purity fine chemicals and stable isotope-labeled compounds.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. The product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.