Description

6-Chloro-3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine is a high-value, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in the strategic combination of a halogenated pyridine ring and a trifluoromethylated pyrazole moiety, offering versatile sites for further functionalization to modulate biological activity and physicochemical properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the discovery and development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical scaffold in medicinal chemistry for the synthesis of potential drug candidates targeting various diseases.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing properties of the trifluoromethyl group.
• Chemical Biology Probe: Serves as a key building block for creating molecular probes to study biological pathways and protein functions.
• Material Science Precursor: Can be utilized in the synthesis of specialized organic materials, such as ligands for catalysts or components for organic electronics.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds for client projects.

Basic Information

Product Name	6-Chloro-3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine
CAS No.	1256835-72-9
Molecular Formula	C7H3ClF3N3
Molecular Weight	221.57 g/mol
Synonyms	6-Chloro-3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine; 1H-Pyrazolo[3,4-b]pyridine, 6-chloro-3-(trifluoromethyl)-; 6-Chloro-3-trifluoromethyl-1H-pyrazolo[3,4-b]pyridine; 6-Chloro-3-(trifluoromethyl)-1H-1,2,3-triazolo[4,5-b]pyridine (incorrect but common misnomer); 6-Cl-3-CF3-Pyrazolopyridine; CTFPP; CAS 1256835-72-9
EINECS	Contact for details

Quality Control

Our 6-Chloro-3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. For projects requiring specific regulatory support, we can discuss compliance with relevant frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.