Description

1,4-Piperazinedicarboxylic Acid, 2-[(1,3-Dihydro-1,3-Dioxo-2H-Isoindol-2-Yl)Methyl]-, 1,4-Bis(1,1-Dimethylethyl) Ester is a sophisticated, high-purity chemical building block designed for advanced organic synthesis. This compound matters for its role as a key protected intermediate in the development of complex pharmaceutical molecules, particularly those targeting neurological and oncological pathways. It is primarily needed by research institutions and pharmaceutical companies engaged in the synthesis of novel active pharmaceutical ingredients (APIs) and complex heterocyclic compounds.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the multi-step synthesis of complex drug candidates, especially those containing piperazine and isoindole motifs.
• Protease Inhibitor Research: Used in the development and scale-up of novel protease inhibitors for therapeutic applications.
• Peptidomimetic Synthesis: Acts as a protected amino acid derivative for constructing peptidomimetics and modified peptides with enhanced stability and bioavailability.
• Chemical Biology Probes: Employed in the creation of specialized molecular probes for studying enzyme function and protein-protein interactions.
• Advanced Material Science: Potential monomer or cross-linking agent in the research of specialty polymers with specific functional properties.
• Contract Research & Manufacturing (CRMO): Supplied to CRMOs for custom synthesis projects requiring high-purity, bespoke intermediates.

Basic Information

Product Name	1,4-Piperazinedicarboxylic Acid, 2-[(1,3-Dihydro-1,3-Dioxo-2H-Isoindol-2-Yl)Methyl]-, 1,4-Bis(1,1-Dimethylethyl) Ester
CAS No.	1256815-06-1
Molecular Formula	C24H33N3O6
Molecular Weight	459.54 g/mol
Synonyms	2-[(1,3-Dioxoisoindolin-2-yl)methyl]-1,4-di-tert-butyl piperazine-1,4-dicarboxylate; 1,4-Di-tert-butyl 2-(1,3-dioxoisoindolin-2-yl)methylpiperazine-1,4-dicarboxylate; tert-Butyl 2-((1,3-dioxoisoindolin-2-yl)methyl)-4-(tert-butoxycarbonyl)piperazine-1-carboxylate; N-Boc-N'-(1,3-dioxoisoindolin-2-ylmethyl)piperazine; Boc-Pip(Nphthal)-OH di-tert-butyl ester; Piperazine-1,4-dicarboxylic acid, 2-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]-, 1,4-bis(1,1-dimethylethyl) ester
EINECS	Contact for details

Quality Control

Our 1,4-Piperazinedicarboxylic Acid, 2-[(1,3-Dihydro-1,3-Dioxo-2H-Isoindol-2-Yl)Methyl]-, 1,4-Bis(1,1-Dimethylethyl) Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere if specified.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.