Description

7-(Trifluoromethyl)Isoquinoline-3-Carboxylic Acid is a high-value, multi-functional heterocyclic building block. This compound is prized for its unique molecular architecture, which combines the isoquinoline scaffold with a carboxylic acid group and a strategically positioned trifluoromethyl moiety. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients. The trifluoromethyl group is a critical pharmacophore known to enhance metabolic stability, lipophilicity, and bioavailability in drug candidates.

Application

• Pharmaceutical Intermediate: A key precursor in the research and synthesis of new drug candidates, particularly for oncology, central nervous system (CNS) disorders, and anti-infective agents.
• Agrochemical Research: Used in developing advanced herbicides, fungicides, and insecticides where the trifluoromethyl group improves efficacy and environmental profile.
• Material Science: Serves as a building block for advanced organic materials, such as ligands for catalysts or components in organic electronic devices.
• Chemical Biology & Proteomics: Employed as a molecular probe or tag due to its distinct chemical handle (carboxylic acid) for bioconjugation.
• Academic & Contract Research: Utilized in universities and CROs for methodological development and exploring new chemical spaces in medicinal chemistry.

Basic Information

Product Name	7-(Trifluoromethyl)Isoquinoline-3-Carboxylic Acid
CAS No.	1256787-80-0
Molecular Formula	C11H6F3NO2
Molecular Weight	241.17 g/mol
Synonyms	7-(Trifluoromethyl)-3-isoquinolinecarboxylic acid; 3-Isoquinolinecarboxylic acid, 7-(trifluoromethyl)-; 7-Trifluoromethylisoquinoline-3-carboxylic acid; 7-(Trifluoromethyl)isoquinoline-3-carboxylic acid; 1256787-80-0; AI3-73754; ZINC000103099777; AKOS040759886; FT-0773297.
EINECS	Contact for details

Quality Control

Our 7-(Trifluoromethyl)Isoquinoline-3-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with each shipment to ensure traceability and compliance with your research or production specifications. Custom purity grades and analytical packages are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). The product is light-sensitive (store away from light). Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥97.0% (Standard Grade)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.