Description

tert-Butyl 6-Cyano-2-(2-(4-Ethyl-3-Iodophenyl)Propan-2-Yl)-1H-Indole-3-Carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its complex indole-based molecular structure. This compound is of significant value for research and development in medicinal chemistry, serving as a critical building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily sought after by pharmaceutical companies and contract research organizations (CROs) engaged in the development of targeted therapies, where precise molecular architecture is paramount.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of novel drug candidates, particularly in oncology and central nervous system (CNS) research.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to optimize the potency and selectivity of lead compounds.
• API Development: Serves as a crucial scaffold for constructing complex molecules intended for clinical trial materials (CTM) and eventual commercial Active Pharmaceutical Ingredients.
• Chemical Biology Probes: Utilized in the development of specialized probes for studying biological pathways and target validation due to its functionalized indole core.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production of investigational new drugs.

Basic Information

Product Name	tert-Butyl 6-Cyano-2-(2-(4-Ethyl-3-Iodophenyl)Propan-2-Yl)-1H-Indole-3-Carboxylate
CAS No.	1256584-75-4
Molecular Formula	C25H27IN2O2
Molecular Weight	514.40 g/mol
Synonyms	6-Cyano-2-[2-(4-ethyl-3-iodophenyl)propan-2-yl]-1H-indole-3-carboxylic acid tert-butyl ester; 1H-Indole-3-carboxylic acid, 6-cyano-2-[2-(4-ethyl-3-iodophenyl)-2-propanyl]-, 1,1-dimethylethyl ester; tert-Butyl 6-cyano-2-(2-(4-ethyl-3-iodophenyl)propan-2-yl)-1H-indole-3-carboxylate; 1256584-75-4; Advanced Indole Intermediate; Pharmaceutical Building Block CAS 1256584-75-4
EINECS	Contact for details

Quality Control

Our production of tert-Butyl 6-Cyano-2-(2-(4-Ethyl-3-Iodophenyl)Propan-2-Yl)-1H-Indole-3-Carboxylate adheres to stringent quality management systems to ensure batch-to-batch consistency and reliability for critical R&D and scale-up processes. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.