Description

Lithium Triisopropyl 2-(5-Chloropyridyl)Borate is a specialized organoboron reagent, a lithium salt of a sterically hindered borate anion. This compound is valued for its role as a highly selective and efficient nucleophile in advanced organic synthesis, particularly in cross-coupling and functional group transformations. It is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require precise and reliable building blocks for complex molecule construction.

Application

• Pharmaceutical Intermediate Synthesis: A key reagent for the introduction of the 2-(5-chloropyridyl) moiety in the development of active pharmaceutical ingredients (APIs).
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a stable boronate source for palladium-catalyzed C-C bond formation to create biaryl structures.
• Agrochemical Research: Used in the synthesis of novel herbicides and insecticides containing chloropyridine derivatives.
• Ligand and Catalyst Preparation: Employed in the synthesis of specialized ligands for transition metal catalysis.
• Material Science: A precursor for creating boron-containing polymers or organic electronic materials.
• Process Chemistry Optimization: Provides a high-purity, consistent reagent for scaling up synthetic routes in kilo-lab and pilot plant settings.

Basic Information

Product Name	Lithium Triisopropyl 2-(5-Chloropyridyl)Borate
CAS No.	1256364-35-8
Molecular Formula	C14H24BClLiNO
Molecular Weight	275.56 g/mol
Synonyms	Lithium (5-Chloro-2-pyridyl)triisopropylborate; Triisopropyl(5-chloro-2-pyridyl)borate Lithium Salt; 2-(5-Chloropyridyl)triisopropylborolithium; Lithium Triisopropyl(5-chloro-2-pyridinyl)borate; (5-Chloro-2-pyridyl)triisopropylboronic acid lithium salt
EINECS	Contact for details

Quality Control

Our production of Lithium Triisopropyl 2-(5-Chloropyridyl)Borate adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot is characterized by NMR (1H, 11B, 13C), HPLC, and elemental analysis. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C in a cool, dry place. This material is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air or moisture must be avoided to maintain reagent integrity.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
NMR Purity (1H)	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.