Description

6-Chloro-1-Methyl-2,4-Bis(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indole is a high-value, multi-functional boronic ester derivative, serving as a critical advanced intermediate in modern synthetic chemistry. Its core value lies in enabling efficient, precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone of pharmaceutical and materials science research. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and organic electronics industries who require reliable, high-purity building blocks for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel indole-based drug candidates, including kinase inhibitors and receptor modulators.
• Agrochemical Synthesis: Used in the research and development of new-generation herbicides and fungicides with complex heterocyclic cores.
• Material Science & OLED Development: Serves as a precursor for creating organic semiconductors, light-emitting materials, and other functional organic electronic components.
• Cross-Coupling Reactions: Primarily utilized in palladium-catalyzed Suzuki-Miyaura couplings to introduce the indole moiety into complex molecules with high fidelity.
• Chemical Biology & Probe Development: Employed in the synthesis of molecular probes and labeled compounds for biological target identification and mechanism studies.
• Academic & Contract Research: A vital reagent for methodology development and complex molecule synthesis in university and CRO laboratories.

Basic Information

Product Name	6-Chloro-1-Methyl-2,4-Bis(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indole
CAS No.	1256360-39-0
Molecular Formula	C23H34B2ClNO4
Molecular Weight	457.63 g/mol
Synonyms	6-Chloro-1-methyl-2,4-bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole; 2,4-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6-chloro-1-methyl-1H-indole; 1H-Indole, 6-chloro-1-methyl-2,4-bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 6-Chloro-1-methyl-2,4-bis(pinacolboron)-1H-indole; 6-Chloro-1-methyl-2,4-di(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole; 2,4-Bis(pinacolatoboryl)-6-chloro-1-methyl-1H-indole; 6-Chloro-1-methyl-1H-indole-2,4-diylbis(boronic acid pinacol ester)
EINECS	Contact for details

Quality Control

Our 6-Chloro-1-Methyl-2,4-Bis(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indole is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, meeting the stringent requirements of research and process chemistry. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR, and MS, to confirm identity and purity. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, ensuring full traceability and compliance with your internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.