Description

n-Cbz-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrrole is a high-purity, protected pyrrole boronic ester derivative, serving as a critical building block in modern synthetic chemistry. Its core value lies in enabling efficient cross-coupling reactions, particularly Suzuki-Miyaura couplings, to construct complex molecular architectures. This advanced intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of drug candidates, especially in constructing heterocyclic cores prevalent in medicinal chemistry.
• Suzuki-Miyaura Cross-Coupling Reactions: Enables the formation of carbon-carbon bonds between the boronate ester and aryl/vinyl halides under mild conditions.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides requiring specific pyrrole-based structures.
• Material Science Research: Serves as a precursor for creating functional organic materials, such as conductive polymers or organic light-emitting diodes (OLEDs).
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological processes and target identification.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing complex organic molecules.

Basic Information

Product Name	n-Cbz-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrrole
CAS No.	1256360-11-8
Molecular Formula	C18H24BNO4
Molecular Weight	329.20 g/mol
Synonyms	1H-Pyrrole-3-boronic acid, 1-[(phenylmethoxy)carbonyl]-, 4,4,5,5-tetramethyl-1,3,2-dioxaborolane ester; 1-Cbz-3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrole; 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrole-1-carboxylic acid benzyl ester; Benzyl 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrole-1-carboxylate; N-Cbz-3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrrole; 1-Carbobenzyloxy-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrrole; 1-Cbz-3-BPin-pyrrole; 3-BPin-1-Cbz-pyrrole
EINECS	Contact for details

Quality Control

Our n-Cbz-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrrole is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications. We adhere to cGMP guidelines for the production of advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.