Description

n-Isopropyl-2-[3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Acetamide is a high-purity, advanced pharmaceutical intermediate featuring a pinacol boronate ester functional group. This compound is critical for enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone of modern medicinal chemistry for constructing complex biaryl structures. It is primarily utilized by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and drug candidates.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) via palladium-catalyzed cross-coupling reactions.
• Medicinal Chemistry Research: Enables the rapid exploration of structure-activity relationships (SAR) by providing a versatile handle for introducing aromatic diversity into lead compounds.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides that require specific biaryl motifs.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the creation of advanced organic electronic materials and polymers.
• Contract Research & Manufacturing (CRO/CMO): Essential raw material for organizations providing custom synthesis and scale-up services.

Basic Information

Product Name	n-Isopropyl-2-[3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Acetamide
CAS No.	1256359-88-2
Molecular Formula	C19H30BNO3
Molecular Weight	331.26 g/mol
Synonyms	3-(2-Isopropylamino-2-oxoethyl)phenylboronic acid pinacol ester; 2-[3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-N-isopropylacetamide; N-Isopropyl-2-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetamide; 3-Acetamidomethylphenylboronic acid pinacol ester (isopropyl amide); B-[3-[(Isopropylamino)carbonylmethyl]phenyl]boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our n-Isopropyl-2-[3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Acetamide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance in cGMP environments for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when prolonged exposure is anticipated to maintain optimal purity and reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.