Description

4-Chloro-1H-Indole-2-Boronic Acid is a high-value boronic acid derivative and a crucial building block in modern synthetic chemistry. Its primary importance lies in its role as a versatile coupling partner in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl and heterobiaryl structures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, particularly for developing novel active pharmaceutical ingredients (APIs) and functional molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of indole-based drug candidates, including kinase inhibitors, receptor antagonists, and other biologically active molecules.
• Agrochemical Research: Used in creating novel herbicides, fungicides, and insecticides that leverage the indole scaffold for enhanced activity.
• Material Science: Serves as a precursor for constructing organic electronic materials, such as OLED (Organic Light-Emitting Diode) emitters and charge-transport materials.
• Chemical Biology & Proteomics: Employed in the development of molecular probes and activity-based protein profiling (ABPP) agents.
• Academic & Contract Research: A fundamental reagent for methodological development in cross-coupling chemistry and heterocyclic compound synthesis.
• Scale-up Synthesis: Suitable for process chemistry and kilogram-scale production under optimized conditions for commercial manufacturing.

Basic Information

Product Name	4-Chloro-1H-Indole-2-Boronic Acid
CAS No.	1256355-59-5
Molecular Formula	C8H7BClNO2
Molecular Weight	195.41 g/mol
Synonyms	4-Chloro-1H-indole-2-boronic acid; (4-Chloro-1H-indol-2-yl)boronic acid; 4-Chloroindole-2-boronic Acid; 2-Borono-4-chloro-1H-indole; 4-Chloro-2-indoleboronic acid; B-(4-Chloro-1H-indol-2-yl)boronic acid; 1256355-59-5
EINECS	Contact for details

Quality Control

Our 4-Chloro-1H-Indole-2-Boronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and batch-to-batch consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our quality commitment supports applications requiring material of pharmaceutical intermediate grade.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its sensitivity, the product should be stored under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation. Keep the container tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.