Description

3-Bromo-5-(Pyrrolidin-1-Yl)Phenylboronic Acid is a sophisticated boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its value lies in its dual functionality, combining a reactive boronic acid group for Suzuki-Miyaura cross-coupling reactions with a bromo substituent and a pyrrolidine moiety, enabling the construction of complex, nitrogen-containing aromatic scaffolds. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries who are developing new active ingredients, particularly for drug discovery programs targeting central nervous system (CNS) disorders and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for candidates with aryl-pyrrolidine pharmacophores.
• Agrochemical Research: Used in creating novel herbicides, fungicides, and insecticides that require specific halogenated, nitrogen-containing aromatic structures.
• Material Science: Employed in the development of organic electronic materials, such as ligands for OLEDs or conductive polymers.
• Chemical Biology & Proteomics: Acts as a versatile handle for bioconjugation and the development of molecular probes and inhibitors.
• Academic & R&D Laboratories: Serves as a valuable reagent for methodological development in cross-coupling chemistry and heterocycle synthesis.
• Ligand Synthesis: Used to prepare complex ligands for catalysis in asymmetric synthesis and transition metal complexes.

Basic Information

Product Name	3-Bromo-5-(Pyrrolidin-1-Yl)Phenylboronic Acid
CAS No.	1256355-16-4
Molecular Formula	C10H13BBrNO2
Molecular Weight	270.94 g/mol
Synonyms	(3-Bromo-5-pyrrolidin-1-ylphenyl)boronic acid; 3-Bromo-5-(1-pyrrolidinyl)benzeneboronic acid; 3-Bromo-5-pyrrolidin-1-ylbenzeneboronic acid; B-(3-Bromo-5-pyrrolidin-1-ylphenyl)boronic acid; 1256355-16-4; 3-Br-5-Pyrrolidin-1-yl-Phenylboronic Acid
EINECS	Contact for details

Quality Control

Our production of 3-Bromo-5-(Pyrrolidin-1-Yl)Phenylboronic Acid adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for research and scale-up applications. Each lot is characterized by advanced analytical techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Typical: 97-99%)
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.