Description

5-((Trimethylsilyl)Ethynyl)Quinoline is a specialized organosilicon building block featuring a quinoline core functionalized with a trimethylsilyl-protected ethynyl group. This compound matters as a versatile intermediate for constructing complex molecular architectures, particularly in advanced materials science and pharmaceutical research. It is primarily needed by R&D chemists and process development scientists in the fields of organic electronics, ligand synthesis for catalysis, and medicinal chemistry for the development of new active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the synthesis of novel quinoline-based drug candidates, particularly for anti-malarial, anti-cancer, and anti-inflammatory applications.
• Organic Electronic Materials: Used as a precursor for constructing conjugated polymers and small molecules for Organic Light-Emitting Diodes (OLEDs) and Organic Photovoltaics (OPVs).
• Coordination Chemistry & Catalysis: Acts as a ligand precursor or a functional handle for attaching quinoline motifs to metal centers in catalytic systems and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Employed in the development of fluorescent tags and molecular probes due to the photophysical properties of the quinoline scaffold.
• Agrochemical Research: Utilized as an intermediate in the discovery and synthesis of new agrochemicals with enhanced properties.
• Academic & Industrial R&D: A valuable reagent for methodology development in cross-coupling reactions (e.g., Sonogashira) and alkyne chemistry.

Basic Information

Product Name	5-((Trimethylsilyl)Ethynyl)Quinoline
CAS No.	1255952-63-6
Molecular Formula	C₁₄H₁₇NSi
Molecular Weight	227.38 g/mol
Synonyms	5-((Trimethylsilyl)ethynyl)quinoline; Quinoline, 5-[(trimethylsilyl)ethynyl]-; 5-(Trimethylsilylethynyl)quinoline; 5-Ethynylquinoline trimethylsilyl ether; TMS-ethynylquinoline; 5-((TMS)ethynyl)quinoline; 5-(Ethynyl)quinoline TMS derivative
EINECS	Contact for details

Quality Control

Our 5-((Trimethylsilyl)Ethynyl)Quinoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.