Description

2-(2-Bromo-1,3-thiazol-4-yl)acetonitrile is a high-purity brominated thiazole derivative, a crucial building block in modern synthetic chemistry. Its value lies in its reactive nitrile and bromothiazole functionalities, enabling the efficient construction of complex heterocyclic scaffolds. This intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, especially in kinase inhibitor and antiviral research.
• Agrochemical Development: Used in constructing advanced fungicides, herbicides, and insecticides with novel modes of action.
• Material Science Research: Serves as a precursor for functionalized polymers and liquid crystals.
• Chemical Synthesis: A versatile reagent for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) and nucleophilic substitutions.
• Library Synthesis: Employed in high-throughput and combinatorial chemistry for generating diverse compound libraries for screening.

Basic Information

Product Name	2-(2-Bromo-1,3-thiazol-4-yl)acetonitrile
CAS No.	1254558-78-5
Molecular Formula	C5H3BrN2S
Molecular Weight	202.06 g/mol
Synonyms	4-(Cyanomethyl)-2-bromothiazole; 2-Bromo-4-thiazoleacetonitrile; (2-Bromo-1,3-thiazol-4-yl)acetonitrile; 2-Bromo-1,3-thiazole-4-acetonitrile; 2-Bromo-4-(cyanomethyl)thiazole; 2-Bromothiazol-4-ylacetonitrile; Acetonitrile, 2-(2-bromo-4-thiazolyl)-; 1254558-78-5
EINECS	Contact for details

Quality Control

Every batch of 2-(2-Bromo-1,3-thiazol-4-yl)acetonitrile is produced and tested under strict quality management protocols. We ensure compliance with relevant industry standards for fine chemical intermediates. A comprehensive Certificate of Analysis (COA), detailing purity, identity, and impurity profiles as determined by HPLC, GC, NMR, and IR spectroscopy, is provided with each shipment to guarantee traceability and consistency for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect stability and reactivity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (GC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.