Description

5-(tert-Butyldimethylsilyloxy)-3-Iodo-1-(Tetrahydro-2H-Pyran-2-Yl)-1H-Indazole is a high-purity, advanced pharmaceutical intermediate designed for complex organic synthesis. This compound is critical for research and development in medicinal chemistry, particularly for constructing novel indazole-based molecular scaffolds. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of active pharmaceutical ingredients (APIs) and other bioactive compounds.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates targeting various therapeutic areas.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for the development of indazole-containing molecules.
• API Synthesis: Serves as a protected and functionalized precursor in multi-step synthetic routes for Active Pharmaceutical Ingredients.
• Chemical Biology Probes: Employed in the development of chemical probes for studying biological pathways and target validation.
• Custom Synthesis: A valuable starting material for contract research organizations (CROs) and CDMOs performing bespoke synthesis for clients.

Basic Information

Product Name	5-(tert-Butyldimethylsilyloxy)-3-Iodo-1-(Tetrahydro-2H-Pyran-2-Yl)-1H-Indazole
CAS No.	1254473-78-3
Molecular Formula	C18H27IN2O2Si
Molecular Weight	458.42 g/mol
Synonyms	3-Iodo-1-(tetrahydro-2H-pyran-2-yl)-5-[(tert-butyldimethylsilyl)oxy]-1H-indazole; 1-(Tetrahydro-2H-pyran-2-yl)-3-iodo-5-[(tert-butyldimethylsilyl)oxy]-1H-indazole; 5-(TBDMSO)-3-Iodo-1-THP-Indazole; 3-Iodo-1-THP-5-(OTBS)-1H-indazole; 1-THP-3-iodo-5-(tert-butyldimethylsilyloxy)indazole
EINECS	Contact for details

Quality Control

Our 5-(tert-Butyldimethylsilyloxy)-3-Iodo-1-(Tetrahydro-2H-Pyran-2-Yl)-1H-Indazole is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to industry-standard analytical protocols, including HPLC, NMR, and MS, to guarantee product integrity.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.