Description

5-((tert-Butyldimethylsilyl)Oxy)-3-Iodo-1H-Indazole is a high-value, protected indazole derivative designed for advanced synthetic chemistry. This compound matters as a versatile and critical building block, enabling the precise construction of complex molecules in pharmaceutical research and development. It is primarily needed by medicinal chemists and process development scientists working on novel drug candidates, particularly in oncology and CNS therapeutic areas.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of targeted small molecule drugs and kinase inhibitors.
• Medicinal Chemistry Research: Used for structure-activity relationship (SAR) studies and lead optimization campaigns.
• API Development: Serves as a precursor in the development and scale-up of Active Pharmaceutical Ingredients (APIs).
• Chemical Biology Probes: Employed in the creation of molecular probes for studying biological pathways and target engagement.
• Cross-Coupling Reactions: The iodine moiety makes it an excellent substrate for palladium-catalyzed cross-coupling reactions like Suzuki, Sonogashira, and Buchwald-Hartwig amination.
• Heterocyclic Compound Library Synthesis: Used for generating diverse libraries of indazole-based compounds for high-throughput screening.

Basic Information

Product Name	5-((tert-Butyldimethylsilyl)Oxy)-3-Iodo-1H-Indazole
CAS No.	1254473-76-1
Molecular Formula	C13H19IN2OSi
Molecular Weight	374.30 g/mol
Synonyms	3-Iodo-5-((tert-butyldimethylsilyl)oxy)-1H-indazole; 1H-Indazole, 5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-iodo-; 5-(tert-Butyldimethylsiloxy)-3-iodoindazole; 5-(TBDMSO)-3-iodo-1H-indazole; 3-Iodo-5-[(tert-butyldimethylsilyl)oxy]-1H-indazole; TBDMS-protected 3-iodo-5-hydroxyindazole; 3-I-5-O-TBDMS-1H-indazole
EINECS	Contact for details

Quality Control

Our 5-((tert-Butyldimethylsilyl)Oxy)-3-Iodo-1H-Indazole is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, essential for sensitive pharmaceutical applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality commitment aligns with cGMP principles for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under inert atmosphere when appropriate for prolonged manipulations.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/IR)	Conforms
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Any single unknown impurity	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.