Description

5-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]-1H-indazole is a high-purity, organosilicon-protected indazole derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its primary value lies in providing a robust, silyl-protected hydroxyl group, enabling precise and selective reactions in complex multi-step syntheses. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active pharmaceutical ingredients (APIs) and fine chemicals where controlled functional group manipulation is paramount.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially in oncology and CNS therapeutic areas.
• Agrochemical Research: Used in the development of new pesticides and herbicides requiring specific indazole-based scaffolds.
• Organic Synthesis Reagent: Acts as a protected precursor for introducing the indazole moiety in complex molecular architectures.
• Material Science: Potential monomer or additive in the research of specialty polymers and advanced organic materials.
• Academic & R&D: A valuable tool for methodological studies in synthetic chemistry, particularly in protection/deprotection strategies.

Basic Information

Item	Detail
Product Name	5-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]-1H-indazole
CAS No.	1254473-74-9
Molecular Formula	C₁₄H₂₂N₂OSi
Molecular Weight	262.43 g/mol
Synonyms	5-[(tert-Butyldimethylsilyl)oxy]-1H-indazole; 5-(TBDMSO)-1H-indazole; 5-(tert-Butyldimethylsilyloxy)indazole; 5-Hydroxy-1H-indazole, TBDMS ether; 1H-Indazole, 5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-; 5-O-TBDMS-1H-indazole; tert-Butyldimethyl(1H-indazol-5-yloxy)silane
EINECS	Contact for details

Quality Control

Our production of 5-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]-1H-indazole adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification and NMR for structural confirmation, to ensure consistency and reliability. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment, supporting your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.