Description

2-Bromo-4-Methyl-Thiazole-5-Carbonitrile is a high-value, multi-functional heterocyclic building block essential for advanced organic synthesis. This compound is prized for its reactive bromine and nitrile functional groups, enabling precise molecular construction in complex chemical architectures. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Used to construct active thiazole cores for next-generation herbicides, fungicides, and insecticides.
• Material Science Research: Serves as a building block for creating functional polymers, liquid crystals, and organic electronic materials.
• Chemical Biology & Proteomics: Employed in the development of activity-based probes and molecular tags for studying biological systems.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions.
• Nitrile Transformation Chemistry: The cyano group can be hydrolyzed to amides or carboxylic acids, or reduced to amines, enabling diverse downstream modifications.

Basic Information

Product Name	2-Bromo-4-Methyl-Thiazole-5-Carbonitrile
CAS No.	1254034-55-3
Molecular Formula	C5H3BrN2S
Molecular Weight	203.06 g/mol
Synonyms	5-Cyano-2-bromo-4-methylthiazole; 4-Methyl-2-bromothiazole-5-carbonitrile; 2-Bromo-4-methyl-5-cyanothiazole; Thiazole, 2-bromo-4-methyl-5-cyano-; 2-Bromo-4-methylthiazole-5-carbonitrile; 1254034-55-3; SCHEMBL21808527; AKOS040759393
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-4-Methyl-Thiazole-5-Carbonitrile is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and development. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles via validated methods such as HPLC, NMR, and GC-MS.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.